Rationality behind banning Ranitidine

Last September passed with sensation of banning and Recall one of  most commonly used  anti hyper-acidity drug, named Ranitidine and its major brand Zantac. News went viral worldwide, immediate action was taken by United States food and drugs administration (FDA), followed by respective authority of Canada, Europe, India and so on. Ranitidine is completely banned to be used by hospital, selling by pharmaceuticals and product was recalled to manufacturer throughout the country as summoned by regulatory body. 

Here, the question is :  how seriously people were being affecting before the news came out ? what are the supporting evidences ? and finally, is matter as serious as claimed ? or being exaggerated ? 

 According to official notice published by FDA and EMA (European medicine agency), a potentially threatening chemical called N-nitrosodimethylamine (NMDA) was detected in Ranitidine, which based upon animal study is carcinogenic. Crucial finding here is that, no any cancer cases are being reported so far in human beings neither during study nor clinical practice. Most importantly, the findings are derived from animal study, which may or may not reproduce in human population exposed to NMDA. Hence, getting triggered t make sense, but the fact is not serious enough for intimidation. 

In fact, NMDA is found to be present more commonly in other daily consumption like meat, Dairy products, vegetables, but  amount present is significantly negligible to cause negative  health impact. 

Evidence behind the claims

Among the negative multi-system  health impact of NMDA, liver is the  most susceptible organ, which can lead to chronic damage and tumorous changes on long term exposure. Risk associated is not only limited to long term use of medications like Ranitidine but also with food products like cured meat. Among various chemical structural of NMDA, B2NMDA is suspected to be hazardous to human organs and tissues like Liver, kidney, lungs, blood platelets. 

Summery

Firstly, public should not use banned product even if they are yet to be recalled. Secondly, care should be taken by industrial workers from rubber, fannery, fish processing, dye, surfactant production industries, where NMDA is used extensively in numerous forms. 

Contaminated water, habit of smoking cigarette should be avoided along with the industrial precautions and regular health check up ( blood and Urine sample) is recommended for individual with relatively high risk.